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  1. About Us
  2. Department Activity
  3. Education & Courses
  4. Publications
  5. Patient Information
  6. Contact Us

Cancer Cytogenetics Department comprises service program and research programs. Cancer Cytogenetics service program is extensively expanded to patients referred from TMH and other medical centers from India. Every year, around 6000 bone marrow / peripheral blood specimens are investigated in cancer patients at diagnosis   and on treatment. The department provides comprehensive profile of tests in Multiple Myeloma (MM), Chronic Myeloid Leukemia (CML), Chronic Lymphocytic Leukemia (CLL), Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Myelodysplastic Syndromes (MDS), Myeloproliferative disorders (MPD) and Lymphomas. The department is NABL (National Accreditation Board for Laboratories) accredited and participates in External Quality Assessment program (EQAS) with College of American Pathologist (CAP). The laboratory staff is highly skilled team of Scientific Officers, Scientific Assistants, Technicians and supportive staff.

1. The department offers specialized diagnostic services in the areas of

• Fluorescence in situ hybridization (FISH) in all Hematolymphoid Malignancies

• FISH on formalin fixed paraffin embedded (FFPE) tissue

• Conventional Karyotyping in CML, AML and MDS / MPD

• Constitutional Karyotyping

• Chromosomal Fragility Studies in Fanconi’s Anemia / Aplastic Anemia

The Department performs more than 60,000 tests annually in all Hematolymphoid Malignancies by FISH and Conventional Karyotyping. The department is committed to provide reliable, accurate reports for diagnosis, prognosis and risk stratification of the disease.

2. The staff regularly participates in National/ International conferences

3. Department conducts 2- 3 days workshop in Cytogenetics for group of students / teaching faculty.

1. Laboratory has translation research programs on Multiple Myeloma, CLL, CML, ALL and is involved in clinical trial programs

2. One month orientation program is conducted in Cancer Cytogenetic for Fellows, DM students, new registrars from Medical Oncology Dept

3. It is involved in short term research projects (dissertation) for Mumbai University M.Sc. Biotechnology program.

4. One year advanced Cancer Cytogenetic Technology course is conducted for Science postgraduates. The training comprises of lectures, hands-on technical      training and microscopy.

5. Observer ship in the department is given to medical post-graduates, scientists, science post-graduates from India and from other countries as well.

6. The scientific members have publications in national and international journals.

  • Rabade N., Raval G., Chaudhary S., Subramanian P.G., Kodgule R., Joshi S., Tembhare P., Hasan K.S., Jain H., Sengar M., Narula G., Banavali S., Kadam P. A., Shetty D., Gujral S., Patkar N. Molecular heterogeneity in acute promyelocytic leukemia - a single center experience from India. Mediterr J Hematol Infect Dis 2018, 10(1): e2018002, DOI: http://dx.doi.org/10.4084/MJHID.2018.002.

  • Dhanlaxmi Shetty, 2017.Pedigree charting- A simple genetic tool for prenatal diagnosis. Talkback-Newsletter of the Indian Society for Prenatal Diagnosis and Therapy(ISPAT), Edition 3, pp-8-11.

  • Usha P Dave and Dhanlaxmi L. Shetty,2016. Array- based Comparative Genomic Hybridization (Array CGH): Future in Prenatal Diagnosis, Chapter 40, section 9 in Prinicpals & Practice in Fetal Medicine. R.

  • P. S. Kadam Amare, H. Jain, S. Kabre, Y. Deshpande, P. Pawar, S. Banavali, H. Menon, M. Sengar, B. Arora, N. Khattry, G. Narula, D. Sarang, S. Kaskar, B. Bagal, H. Jain, Uma Dangi, P. G. Subramanian, S. Gujral. Cytogenetic Profile in 7209 Indian Patients with de novo Acute Leukemia: A Single Centre Study from India. Journal of Cancer Therapy, 2016, 7, 530-544.

  • P. S. Kadam Amare, S. Kakade, K. Chopra, M. Sengar, H. Menon, H. Jain, B. Bagal, P. G. Subramanian, S. Gujral. Comprehensive Genetic Analysis by Integration of Conventional Karyotyping and Interphase FISH Helps Refinement of Biological Subclasses with Clinical Impact in Chronic Lymphocytic Leukemia. Journal of Cancer Therapy, 2016, 7, 427-438.

  • P. S. Kadam Amare, H. Jain, S. Kabre, D. Walke, H. Menon, M. Sengar, N. Khatri, B. Bagal, U. Dangi, H. Jain, P. G. Subramanian, S. Gujral. Characterization of Genomic Events Other than Ph and Evaluation of Prognostic Influence on Imatinib in Chronic Myeloid Leukemia (CML): A Study on 1449 Patients from India. Journal of Cancer Therapy, 2016, 7, 285-296.

  • Dhanlaxmi L. Shetty, Akshay P. Kadam, Neeraja T. Koppaka, Rupa C. Dalvi, Deepak S. Chavan, Bibu R.Das, and Swarna Mandava, 2014.X-autosome translocations in amenorrhoea: a report of a three way translocation from Indian Population.Gynecol Endocrinol;Apr;30(4):302-6.

  • Dave Usha and Shetty Dhanlaxmi. Mutational Screening and Prenatal Diagnosis in Cornelia de Lange Syndrome. J Obstet Gynaecol India. 2014 Feb; 64(1): 27–31.

  • Neeraja Koppaka, Rupa Dalvi, Dhanlaxmi L. Shetty, B.R. Das and Swarna Mandava. Balanced autosomal translocation in Primary amenorrhoea and A Report of Double Robertsonian Translocation from Indian population. International Journal of Gynecology and Obstetrics,116 (2012);253-257.

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Information for Outside Referrals

If you wish to refer tests for Cancer Cytogenetic Department, please send relevant details of the patient; i.e. name, age, sex, sample type (BM/ PB), sample collection date and time, diagnosis, clinical history, duration of illness should be given in the reference letter along with address, telephone number and e-mail address.

Sample Collection Details

  • 2 - 4 ml  Bone Marrow Sample / Peripheral Blood Sample  to be collected in sterile Sodium Heparin vaccutainer and sent immediately after collection.  In case, the sample cannot be sent on the same day kindly store the sample at 4 Degree and send it next day, preferably with an Ice Pack. Please send clinical details and also attach the immunophenotype report. Kindly provide the address and email ID to dispatch the reports. Kindly mail the clinical details on cytogenetic@actrec.gov.in

  • Kindly note 3 - 6 ml Bone marrow sample is required for Multiple Myeloma test.

  • Payment details will be shared to Outside Mumbai Patients after contacting the department

  • For Fanconi Anemia / Aplastic Anemia testing, kindly give a call on 022 2740 5000 Extn – 5759

Phone: Department Office Number: (+9122) 27405000 / Ext.No. 5758 /5759

Address: Cancer Cytogenetic Department, CCE Building, Room no -06,

ACTREC, Sector -22, Kharghar, Navi Mumbai – 410210

Maharashtra, India

Fax: Hospital Fax Number: (+9122) 27405000 / Ext.No. 5758 /5759

Email-id: Email-id: cytogenetic@actrec.gov.in

Contact Us

TATA MEMORIAL HOSPITAL
Dr. E Borges Road, Parel, Mumbai - 400 012 India
Phone: +91-22- 24177000, 24146750 - 55
Fax: +91-22-24146937
E-mail : msoffice@tmc.gov.in (for patient care and queries) / hrd@tmc.gov.in(for administrative - HRD matters)

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