Title
|
Adjuvant Radiotherapy in Early Stage Oral Cancers (AREST) – a prospective randomized control trial. Study design / Type : A prospective randomized control trial |
Investigators
|
Dr. Sudhir Nair |
Participating Centres
|
|
Number of participants
|
392 |
Status
|
Recruitment started in TMH |
Synopsis
|
Oral cancer is one of the commonest cancer affecting men in India. Surgery is the preferred initial mainstay of treatment for these patients in our institute. The predominant pattern of failure for oral cancers remains loco-regional recurrence. Various retrospective reports including data from Tata Memorial Centre suggests that depth of invasion is an important factor affecting prognosis in early stage oral cancers. Some centers therefore, advice adjuvant radiotherapy for these tumors based on tumor thickness / depth of invasion alone even in the absence of other adverse prognostic factors. However, no direct evidence exists for the effectiveness of radiotherapy in improving disease-related outcomes in patients with depth of invasion as the only adverse prognostic factor. |