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RESEARCH

Several research projects are being carried out in the department. Majority of these are investigator initiated and some of them are multicentric.

PROJECTS

 

Title of Project and investigators

Date of Starting

Funding body

Ongoing Projects

1

Concomitant chemoradiotherapy versus accelerated radiotherapy versus conventional radiotherapy in the management of advanced carcinoma of the head and neck. S. (Ghosh) Laskar, JP Agarwal, TK Saikia, KA Dinshaw

2000

TMH/ CSIR

2

Randomized multicentric study of 5 v/s 6 weekly fractions of radiotherapy in the treatment of squamous cell carcinoma of head & neck. JP Agarwal, SK Shrivastava, S (Ghosh) Laskar, KA Dinshaw

2000

IAEA/TMH

3

Intraoperative Iridium - 192 tumor bed implant alone in early breast cancer. Sarin R, Jalali R, Budrukkar AN, Badwe R, Parmar V, Nadkarni M, Chinoy R, Shet T, Shrivastava SK, Deshpande DD, Dinshaw KA

2001

Nil

4

HDR Brachytherapy Of Internal Mammary Nodal Chain In Breast Cancer With Intra-Operative Catheter Placement In The Internal Mammary Vessels. Sarin R, Badwe R, Jalali R, Mahantshetty U, Budrukkar A, Parmar V, Nadkarni M, Deshpande DD

2001

Nil

5

Feasibility study to evaluate and correlate between clinical & sonographic responses in cervical node metastases in head & neck carcinoma following radical radiotherapy. S (Ghosh) Laskar, JP Agarwal, S Arya, T Pandey, P Corea

2002

TMH

6

Concomitant chemoradiation in advance stage carcinoma cervix- A phase III Randomised trial. SK Shrivastava, HB Tongaonkar, S Gupta, R Kerkar, A Maheshwari, S (Ghosh) Laskar, KA Dinshaw

2003

TMH/ ICMR

7

Concomitant chemoradiation versus neo-adjuvant chemotherapy and surgery in the management stage II carcinoma cervix- A phase III Randomised trial, S Gupta, HB Tongaonkar,SK Shrivastava, eshwari, S (Ghosh) Laskar, KA Dinshaw

2003

TMH/ ICMR

8

Intraluminal HDR brachytherapy alone versus Intraluminal HDR brachytherapy and External Beam Radiotherapy in the Palliation of Advanced Oesophageal Carcinoma. KA Dinshaw, S Ghosh Laskar, SK Shrivastava, DD Deshpande, RA Kinnhikar

2003

IAEA/TMH

9

Two vs four cycles of abvd chemotherapy and low dose radiation therapy in early stage favourable prognosis hodgkin's disease: a randomised clinical trial.M.A.Muckaden, .S. Laskar, T.K.Saikia, S.K.Pai, K.Naresh, S.Gupta

2003

TMH

10

Hereditary Cancer Consortium. R Sarin, SS Agarwal, KA Dinshaw K Mohandas, P Kurkure, R Badwe, H Tangaoankar, A Puri, R Chinoy, R Mulherkar, P Kadam

2002

TMH

11

Accelerated Tumor Bed Irradiation in Early breast cancer with IMRT: A Feasibility and dosimetric study. R Sarin S Chopra, D Kumar, SS Narayanan, R Kamble, R Jalali, SK Shrivastava, DD Deshpande, K A Dinshaw

2003

TMH

12

Efficacy of stereotactic conformal radiotherapy (SCRT) compared to conventional radiotherapy in minimising late sequelae in children and young adults with brain tumours: a randomised clinical trial (SCRT trial). R Sarin, R Jalali, N Merchant, S Goswami, N Shah, KA Dinshaw, et al

2001

Terry Fox Foundation

13

To prospectively compare tumour control, late sequalae and quality of life in patients with non-functioning pituitary adenomas treated with surgery alone versus surgery followed by radiotherapy: a randomised trial (pituitary trial). R Jalali, A Goel, R Sarin, et al

2002

TMH

14

Radioprotective effect of ocimum sanctum (Tulsi) in patients undergoing hemibody irradiation: A double blind randomised trial R Sarin, R Jalali, SK Shrivastava, MA Muckaden, M Ghatge, AS Raste, KA Dinshaw

2002

ICMR grant

15

Prevalence and spectrum of BRCA1 and BRCA2 mutations in familial breast ovarian cancers. R Sarin, SS Agarwal, R A Badwe, HB Tangaoankar, K.A Dinshaw

2004

TMH

16

Prospective neurological function, quality of life and Barthel's assessment in adult patients with primary brain tumours. R Jalali, A Bud, R Sar, R Kamble, S Parab, R Hawaldar

2004

TMH

17

Feasibility of concomitant electron boost (on Saturdays) in patients with locally advanced breast cancer treated with radiotherapy R Jalali, R Malde, A Budrukkar, R Sarin

2004

TMH

18

Para-aortic Lymph Node Staging and Evaluation of Treatment Outcome by 18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in Advanced Cancer Cervix. KA Dinshaw, SK Shrivastava, A Samuel, HB Tongaonkar, R Kerkar, A Maheshwari, S (Ghosh) Laskar.

2004

TMH

19

Elective versus Therapeutic Neck Dissection in the Treatment of Early Node Negative Squamous Cell Carcinoma of the Oral Cavity, AK D'cruz, D Chaukar, KA Pathak, M Deshpande, P Chaturvedi, P Pai, RL Bhalawat, S. (Ghosh) Laskar, JP Agarwal, KA Dinshaw

2004

TMH

20

Randomized Clinical trial to compare results of Concurrent chemo-radiation with surgery and post-operative radiotherapy. KA Pathak, M Deshpande, AK D'cruz, D Chaukar, P Chaturvedi, P Pai, RL Bhalawat, S. (Ghosh) Laskar, JP Agarwal, PM Parikh, VR Pai, KA Dinshaw

2004

TMH

21

A phase II trial of IRESSA in advanced Head & Neck cancers. D'cruz, D Chaukar, S. (Ghosh) Laskar, JP Agarwal, KA Dinshaw

2004

Multicentric: ASTRA-ZENECA

22

Radiotherapy Dose Escalation for Inoperable Ewing's Sarcoma/ PNET (EFT 2001 RT). S.Laskar, C.N.Nair, M.A.Muckaden, A.Puri, M.G.Agarwal, S.Gujral, S.Gupta, S.Banavali,P.Kurkure, S.K.Pai, S.Juvekar, N.Nair,D.D.Deshpande, S.K.Shrivastava, S.Basu.

2004

DAE/ CTC

23

Intensified Vincristine, Ifosfamide, Etoposide with Adriamycin, Cyclophosphamide, and Actinomycin D in the Treatment of Non-Metastatic Ewing's Family of Tumors. C.N.Nair, M.A.Muckaden, S.Gupta, S.Banavali, S.K.Pai, P.A.Kurkure, S.Laskar, A.Puri, M.G.Agarwal, S.Juvekar, T.Shet, M.Ramadwar, S.Desai, S.Agarwal, N.Nair, R.Havaldar.

2004

TMH

24

Intensive versus Routine follow-up for Soft Tissue Sarcomas. A.Puri, M.G.Agarwal, R.Badwe, R.Hawaldar, R.Mistry, C.S.Pramesh, S.Laskar, S.Gupta, N.Jambhekar, M.A.Muckaden, S.Juvekar.

2004

TMH

25

The Treatment and Characterization of Acute Lymphoblastic Leukemia in Children, Adolescents and Young Adults (INCTR 02-04). S.Banavali, P.Kurkure, C.N.Nair, P.M.Parikh,S.K.Pai, S.Gujral, M.A.Muckaden, S.Laskar, N.Merchant, S.Goswami, P.Amre, A.Paes, B.Kolhatkar, R.Hawaldar, N.Thomas.

2004

TMH/ INCTR

26

Concomitant and adjuvant Temozolomide with radical radiotherapy in children with brain stem glioma (brain stem glioma study). R.Jalali, P.Kurkure, R.Sarin, N.Merchant, T.Gupta

2004

Hospital Intramural grant

27

IMRT for Craniospinal irradiation (CSI) - will have preclinical component of dosimetric/modelling work followed by implementation and feasibility in 5 patients (IMRT-CSI study). R.Jalali, D.Sharma, R.Sarin, T.Gupta, Reena.P, S.K.Shrivastava, K.A.Dinshaw

2004

DAE/CTC

28

A phase II randomized trial Comparing IMRT with conventional radiation therapy in Stage IIB Carcinoma Cervix.SK Shrivastava, U Mahantshetty, DD Deshpande, S (Ghosh) Laskar, KA Dinshaw, RA Kinhikar, Sherly Saju, SV Jemima, HB Tongaonkar, S Gupta.

2004

Varian Medical Systems LTD.USA

29

Phase II study of 3-Dimentional Conformal Radiotherapy (3D-CRT) versus Intensity Modulated Radiotherapy (IMRT) for Squamous Cell Carcinoma of the Head & Neck (HNSCC).SG Laskar, T Gupta, JP Agarwal, SK Shrivastava, KA Dinshaw, PM Parikh, VR Pai, Reena Devi, S Deshpande, DD Deshpande.

2005

Varian Ltd, USA

30

Phase II study of 3-Dimentional Conformal Radiotherapy (3D-CRT) versus Intensity Modulated Radiotherapy (IMRT) for Squamous Cell Carcinoma of the Head & Neck (HNSCC).Gupta T, Laskar SG, Agarwal JP, Shrivastava SK, Dinshaw KA, Parikh PM, Pai VR, Reena Devi, Deshpande S, Deshpande DD.

2005

Siemens Ltd., USA

31

Para-aortic Lymph Node Staging and Evaluation of Treatment Outcome by 18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in Advanced Cancer Cervix. Dinshaw KA, Shrivastava SK, Samual A, Mahantshetty U, Laskar SG, Merchant NH, Gupta S, Tongaonkar HB, Rangrajan V, Purandare N.

2005

DAE/CTC

32

Comparative evaluation of different detectors for IMRT dosimetry. Deshpande DD, Kinhikar RA, Saju Sherley, Narayana SS, Sharma D, Shrivastava SK, Dinshaw KA.

2005

Intramural / ACTREC

33

Phase III Trial of Surgery followed by conventional radiotherapy (5#/Wk) versus concurrent chemoradiotherapy versus Accelerated radiotherapy (6#/Wk) in high risk, locally advanced, stage III & IVa, resectable, squamous cell carcinoma of oral cavity. Deshpande Mandar, D'Cruz AK, Pathak KA, Chaukar DA, Chaturvedi P, Pai P, Dinshaw KA, Bhalavat RL, Agarwal JP, Ghosh S, Pai VR, Mohandas K, Kane SV

2005

DAE-CTC

34

Temozolomide versus PCV in recurrent high grade gliomas (BR 12 Trial). A MRC conducted multicenter randomised trial -R Jalali (Collaborator from TMH).

2005

MRC/ TMH

35

Timing of systemic chemotherapy in patients with isolated locoregional recurrence of breast cancer. Nair R, Gupta S, Badwe R, Parmar V, Nadkarni M, Sarin R, Jalali R, Budrukkar AN, Hawaldar R

2005

36

A phase III trial evaluating the role of chemotherapy as an adjuvant therapy for premenopausal women with endocrine responsive breast cancer who receive endocrine therapy (PERCHE trial). Parmar V, Badwe R, Nadkarni M, Nair R, Gupta S, Sarin R, Jalali R, Budrukkar AN, Hawaldar R

2005

IBCSG

37

A phase III trial evaluating the role of exemestrane plus GnRH analogue as an adjuvant therapy for premneopusal women with endocrine responsive breast cancer (TEXT trial) Parmar V, Badwe R, Nadkarni M, Nair R, Gupta S, Sarin R, Jalali R, Budrukkar AN, Hawaldar R

2005

IBCSG

 

 

Contact Us

TATA MEMORIAL HOSPITAL
Dr. E Borges Road, Parel, Mumbai - 400 012 India
Phone: +91-22- 24177000, 24146750 - 55
Fax: +91-22-24146937
E-mail : msoffice@tmc.gov.in (for patient care and queries) / hrd@tmc.gov.in(for administrative - HRD matters)

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