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  • Efficacy Of Stereotactic Conformal Radiotherapy (SCRT) Compared To Conventional Radiotherapy In Minimising Late Sequelae In Children And Young Adults With Brain Tumours : A Randomised Clinical Trial
  • Hereditary Cancer Consortium
  • Three field radical esophagectomy versus two field esophagectomy a prospective randomized controlled trial
  • Concomitant Chemo-radiation in Advanced Stage Carcinoma Cervix : A Phase III Randomized Trial
  • A prospective randomized trial of neo-adjuvant chemotherapy and surgery versus concurrent chemoradiation therapy in patients with stage IB2-IIB squamous carcinoma of the uterine cervix
  • Establishment of ICMR National Tumor Tissue Repository (INTTR) at the Tata Memorial Centre
  • Elective versus Therapeutic Neck Dissection in the treatment of early node negative squamous cell carcinoma of the oral cavity
  • Radiotherapy dose escalation for inoperable Ewings Sarcoma / PNET (EFT2001 RRT)
  • A Randomized trial to assess the impact of loco-regional treatment on survival of patients with metastatic breast cancer at first presentation.
  • A Phase - II Randomized Trial Comparing Intensity Modulated Radiation Therapy (IMRT) with Conventional Radiation Therapy in stage II-B Carcinoma of Cervix
  • Are Treatment Outcomes Predetermined ? An Observational Study Using Astrological Prediction
  • Phase III trial of surgery followed by conventional radiotherapy (5 fractions/ week) vs concurrent chemoradiotherapy vs accelerated radiotherapy (6 Fractions/week) in high risk, locally advanced stage III & iva, resectable, squamous cell carcinoma of oral cavity
  • An Adequate Cost Effective Follow Up Protocol For Bone and Soft Tissue Sarcomas. A Prospective Randomized Trial
  • A Phase III Trial Evaluating The Role Of Ovarian Function Suppression And The Role Of Exemestane As Adjuvant Therapies For Premenopausal Women With Endocrine Responsive Breast Cancer (SOFT Trial)
  • A Phase III Trial Evaluating The Role Of Exemestane Plus GnRH Analogue As Adjuvant Therapy For Premenopausal Women With Endocrine Responsive Breast Cancer (TEXT Trial)
  • Optimizing treatment of cervix cancer using radiotherapy and analysis of virally-associated cellular resistance (IAEA project No: 13041)
  • Cervix Cancer Screening by two step (VIA and HIV DNA Tests) technique, among low socio economic population in Mumbai, India
  • Evaluation of CD 26 expression in donor cell and its correlation with engraftment in Hematopoietic Stem Cell Transplantation
  • Optimizing the physical and biological parameters in craniospinal irradiation (CSI) for average risk medulloblastoma: a feasibility study
  • Validation of gamma irradiation of blood using the indigenous blood irradiator BI 2000
  • Phase II study of laproscopic anterior resection (AR) and abdominoperineal resection (APR) for carcinoma of the rectum, rectosigmoid and anorectal lesions
  • Study of the expression of Apoptosis-related genes in human oral cancers
  • Inter laboratory comparison program for immunophenotyping by flow cytometry
  • Comparison of cardiovascular effects (ECG) of intravenous Ondansetron and Granisetron in patients undergoing surgery for carcinoma breast.
  • International, Randomized, Open-Label, Phase  3 Trial of Gemcitabine/Cisplatin Plus PF-3512676 Versus Gemcitabine /Cisplatinalone as first-line treatment of patients with advanced Non Small Cell Lung Cancer
  • A Randomized Open Label, Multicenter, Phase 3 Study of Epoetin Alfa plus standard Supportive Care versus standard Supportive Care in Anemic Patients with Metastatic Breast Cancer Receiving First Line Standard Chemotherapy
  • PCR assays for the early and rapid diagnosis of fungal infections in high risk cancer patients on aggressive chemotherapeutic protocols
  • Pattern of care and survival studies  cervix cancer
  • Pattern of care and survival studies  Breast cancer
  • Pattern of care and survival studies  Head and Neck cancer
  • An Open Label Randomized Phase II Study of Two Different Dosing Regimens of Capacetabine in Combination with Intravenous Docetaxel (Q3W) in Patients with Locally Advanced and / or Metastatic Breast Cancer
  • 26866138-LYM-3001- A randomized, Open-Label, Multicenter Study of VELCADE, with Rituximab or Rituximab  Alone in Subjects with Relapsed or Refractory, Rituximab Naïve or Sensitive Follicular B-cell Non Hodgkin’s Lymphoma
  • A Phase III, Randomized, Double-Blind, Parallel-Group, Study to Assess the Efficacy of ZD 6474 (ZACTIMA TM) Versus Erlotinib (TARCEVA ®) in Patients With Locally Advanced or Metastatic (Stage IIIB  IV) Non-Small Cell Lung Cancer (NSCLC) after Failure of at least One Prior Cytotoxic Chemotherapy
  • Intensity modulated radiation therapy (IMRT) for women with large breast undergoing Breast Conserving Therapy (BCT)
  • Radiation therapy to the metabolically active target volume in paranasal sinuses: Feasibility study of image fusion of PET-CT with MRI20 and Radiation dose escalation
  • Needs analysis of service users in pediatric palliative care
  • A randomized trial of concurrent versus sequential  Tamoxifen with radiotherapy to assess the extent of pulmonary fibrosis and disease related control and survival in breast cancer patients
  • Mucins in colloid carcinoma and infiltrating micro papillary carcinomas  Searching for the link between the two?
  • A case-control study to investigate risk factors for gall bladder cancer
  • A Case-Control study to investigate risk factors for lung cancer among non smokers
  • Standardization and validation of protocols for long and short term storage of biological materials in Tissue Repository
  • Does Anemia Increase Plasma Clearance of Anti neoplastic Drugs- A Proof of Principle Study
  • Reliable, simple and quick study for diagnosis of pre-operative nutritional depletion using the CT-Scan done for cancer staging. RESQ Study
  • Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in women with LOBC and LABC
  • A prospective study to evaluate the role of FDG PET/CT and CE-CT in the assessment of pelvic and retroperitoneal lymph node metastases in patients with operable cervical and endometrial cancers
  • Evaluation of Zolendronic acid as a single agent or an adjuvant to chemotherapy in the management of high grade osteosarcoma
  • Identification of molecular subclasses of medulloblastomas by genome-wide expression analysis coupled with array-CGH
  • Phase I/II study of SKI-606 IN Philadelphia Chromosome Positive Leukemias (Protocol Number:3160A4-200-WW)
  • An observational study to compare the efficacy of Povidone-Iodine 10% and Chlorhexidence 2% for  skin disinfection during placement of epidural and central venous catheters. A pilot study of 60 patients.
  • Head shaving in neurosurgery implications on surgical site infection and cosmesis  a feasibility study
  • Refinement of surgical treatment of posterior fossa tumors : Evaluation of craniotomy (vis-à-vis craniectomy) and defining the role of  CSF (cerebrospinal fluid) diversion
  • Comparative analysis of diffuse large B cell lymphoma in HIV/AIDS vs. in immunocompetent patients from India and in West
  • Prospective, collaborative, multi-center multi-national, open cohort study evaluating device associated nosocomial infection rates, extra days, extra costs, antibiotic use, bacterial resistance, mortality, risk factors, infection control process surveillance and cost effectiveness in coronary, medical surgical, mixed, adults, pediatric and newborns intensive care units in Health care settings
  • An international phase III, randomized, double blinded, Placebo controlled, multi-center study to assess the efficacy of ZD6474 (ZACTIMATM) versus placebo in subjects with unresectable locally advanced or metastatic medullary thyroid cancer
  • Lymphatic mapping and sentinel node identification in patients with stage Ib1 cervical carcinoma (Protocol GOG-0206)
  • Risk factors for colorectal cancer in India: INDOX Case-control study
  • Case control study of breast cancer in Mumbai comparing rural and urban women
  • ALTO-EGF106708- A randomized, multi-center, open-label, phase IIIstudy of adjuvant Lapatinib,Trastuzumab, their sequence and their combination in patients with HER2/ErbB2 positive primary breast cancer
  • Application of FDG-PET and molecular gene profiling for risk stratification of diffuse large B-cell Non Hodgkin’s Lymphoma in different ethnic populations
  • Peripheral T cell and NK cell lymphomas prognostic impact of cytotoxic characteristics and association with Epstein Barr Virus
  • Burkitt like lymphomas  in search of morphologic, clinical and immunophenotypic characteristics
  • A prospective study to compare the accuracy of ultrasound guided fine needle aspiration cytology and sentinel node biopsy in staging of clinically uninvolved neck in patient with T1 and T2 oral cancers
  • Detection of molecular and immunohistochemical markers in high grade osteogenic sarcoma  a tumor with highest incidence in paediatric patients
  • A phase II study to evaluate the role of conformal hepatic radiation in unresectable hepatocellular carcinoma and hepatic metastases
  • Phase II randomized trial comparing neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locoregionally advanced oesophageal cancer
  • A case control study to identify risk factors for prostate cancer
  • Pilot study of helical Tomotherapy based radiation therapy for the treatment of cancers
  • Quantitative estimation and evaluation of HPV 16/ 18 DNA in pre-treatment, post treatment and follow up evaluation in carcinoma cervix IB2-IIIB treated with radical radiation or chemo-radiation therapy an observational study
  • Pathogenesis of neutropenic sepsis : the role of Toll-like receptors, free DNA and head shock protein
  • Comparative study of targeted sentinel node biopsy versus axillary sampling in clinically node negative breast cancer after neoadjuvant chemotherapy
  • Transfusion of ABO-non identical single donor platelets. A prospective observational study
  • Utility of  FDG PET/CT scans in evaluation of disease extent and treatment response of tuberculosis
  • Role of plasma BNP (Brain, natriuretic peptide) levels  as a screening test for anthracycline induced cardiotoxicity:a pilot study
  • Evaluation of predictive value of urinary EBV DNA estimation, its correlation with plasma EBV DNA and radiological responses in patients with locally advanced nasopharyngeal carcinoma undergoing treatment
  • Determination of the rate of alloimmunisation and refractoriness to platelet transfusions in multi-transfused  thrombocytopenic patients and the impact of leucocyte depletion: a pilot study
  • The risk of hepatocellular carcinoma in patients with chronic liver disease of viral etiology and iron deficiency
  • An open labeled, phase III study comparing intravenous iron sucrose v/s oral ferrous sulphate in the treatment of cancer related anemia
  • Efficacy of pasteurisation of resected tumor bearing bone and immediate reimplantation in surgical treatment of malignant bone tumours
  • To study the expression levels of class I and II histone deacetylase (HDAC) genes before and after in-vitro treatment with valproic acid (VPA) in patients with newly diagnosed relapsed and  refractory acute myeloid leukemia (AML)
  • Management of fungating wound using honey
  • Role of proteasomes in Neural Stem Cell differentiation  a preliminary standardization study
  • MDCT in preoperative staging of gastric carcinoma
  • MDCT evaluation of mandibular  invasion in oral squamous cancers
  • A prospective observational study of radiotherapeutic variables influencing acute radiation toxicity, cosmesis and quality of life of breast cancer patients
  • An observational study of haemodynamic changes during induction of anaesthesia in patient with and without diabetic autonomic neuropathy, undergoing elective cancer surgery
  • A prospective observational study of the utility of clinical pre-operative predictors of difficult intubation
  • Time taken for intubation and need for external laryngeal manipulation with two different laryngoscope blades-An observational study
  • A retrospective analysis of  mediastinal FNAC’s and correlation with histopathology
  • A retrospective observational study of prevalence and treatment profile in metastatic bone pain in the past 2 years at TMH, Mumbai
  • Kikuchi’s Disease- Retrospective clinicopathological study
  • An observational study of Propofol vs Midazolam for short term sedation in mechanically ventilated patients
  • To study cosmetic outcome in patients undergoing breast conservation surgery with oncoplastic techniques
  • A retrospective study of patterns of bone marrow involvement in T-Cell and NK-Cell Non-Hodgkin’s Lymphoma
  • Palm print as a sensitive predictor of difficult laryngoscopy in diabetes: A comparison with other airway evaluation indices
  • 177 Lu-EDTMP in hormone refractory prostate cancer patients with bone metastases: a phase I activity escalation study. Co-ordinated research project- IAEA
  • An observational study of visualization of laryngeal inlet and ease of intubation with different laryngoscope blades.
  • A prospective study of sentinel lymph node biopsy for extremity sarcomas with propensity for lymphatic metastases using indigenous gamma probe for Tc 99m sulfur colloid and blue dye
  • Evaluation of Efficacy and Toxicities of Total Body Irradiation (TBI) based Conditioning Regimen by Tomotherapy in Patients of Acute Leukemia undergoing Allogeneic Hematopoietic Stem Cell Transplantation
  • Development of a cohort study to identify and evaluate transitions in lifestyle and risk factors in a rural population with a low cancer disease risk at baseline.
  • 3160A4-3000-WW: A phase III randomized, open label study of Bosutinib versus Imatinib in subjects with newly diagnosed chronic phase Philadelphia Chromosome Positive Chronic Myelogenous Leukemia
  • Effectiveness and safety of 2 versus 3 doses of HPV Vaccine in preventing cervical cancer: An Indian multi-centre randomized trial
  • IBCSG 35-07/BIG1-07 (SOLE)A phase III trial evaluating the role of continuous letrozole versus intermittent letrozole following 4 to 6 years of prior adjuvant endocrine therapy for  postmenopausal women with hormone-receptor positive, node positive early stage breast cancer
  • Phase-II study evaluating the role of tomotherapy - based intensity modulated radiotherapy and brachytherapy in post surgery recurrent carcinoma cervix.
  • Oncogenic genetic alterations in Thyroid Cancer patients in Indian population and their clinicopathological relevance
  • A phase III study of Pemetrexed, Cisplatin, and Radiotherapy followed by consolidation Pemetrexed versus Etoposide, Cisplatin, and Radiotherapy Followed by consolidation cytotoxic chemotherapy of choice in patients with unresectable, locally advanced, stage III non-small cell lung cancer other than predominantly squamous cell histology[protocol H3E-MC-JMIG]
  • Concurrent Chemoradiation using tomotherapy based IMRT in locally advanced gallbladder and pancreatic cancers: A  feasibility study.
  • A European Study on MRI -guided Brachytherapy in locally Advanced cervical cancer (EMBRACE) (Endorsed by GEC ESTRO)
  • A questionnaire survey to assess the quality of informed consent among clinical trial participants
  • Development of In Vivo Laser Raman Spectroscopic Methods for Diagnosis of Oral Precancerous and Cancerous Conditions
  • Development of Raman Microspectroscopic methods for Diagnosis of Cervical Preinvasive and invasive Carcinomas
  • Detection of kinase domain mutations in CML patients after development of resistance, by sequencing and flow cytometry and studying the efficacy of increased dose of imatinib to overcome these mutations.
  • To Prospectively study the role of MDCT in Staging of Primary Ovarian Malignancy
  • Prevalence and effect of malnutrition in children with cancer- a prospective observational study.
  • Imatinib pharmacokinetics and its correlation with response and safety in Indian children and adults with chronic phase chronic myeloid leukemia
  • microRNA control of WNT signalling pathway in medulloblastoma, a common paediatric malignant brain tumour
  • Prognostication in neuroblastoma by detection of MYCN amplification by  fluorescent and chromogenic in situ hybridization, quantitative and qualitative PCR analysis
  • Toxicity with tomotherapy based IMRT in Head and Neck cancers and in-vivo prediction of radio-responsiveness of oropharyngeal cancers using Raman Spectroscopy
  • Multicentre, randomised, double-blind, Phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard docetaxel therapy compared to placebo plus standard docetaxel therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy.
  • A pharmacokinetic-pharmacodynamic study assessing the ability of curcumin to decrease cytokines involved in mucositis in the autologous transplant setting
  • Comparison of Immune response pattern in nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich B cell lymphoma
  • Role of keratins 8,18 and vimentin during epithelial-mesenchymal transition (EMT) using oral organotypic co-culture model
  • Randomized intervention trial to evaluate single and double freeze cryotherapy in the prevention of cervical neoplasia
  • Safety and Efficacy of oral valproate in recurrent / progressive brain tumours
  • A Randomized Controlled Trial of Neoadjuvant Weekly Paclitaxel versus Weekly Paclitaxel Plus Weekly Carboplatin in Women with Triple Negative Breast Cancer
  • An observational phase II study of the efficacy of metronomic chemotherapy in patients with relapsed epithelial ovarian carcinoma with elucidation of its potential mechanisms of action by study of angiogenesis and apoptosis
  • Investigating the role of interdomain mobility and conformational switches in regulation of Serine Protease activity of HtrA2/Omi
  • ICMR task force for immunophenotyping of hematolymphoid neoplasm by flow cytometry and setting up of external quality assurance scheme at TMH, Mumbai
  • The role of neoadjuvant chemotherapy for mandibular preservation in locally advanced operable squamous cell carcinoma of the oral cavity
  • BIG1-06/EGF106903: A randomized, multicenter, open-label, phase III study of neoadjuvant lapatinib, trastuzumab and their combination plus paclitaxel in women with HER2/ErbB2 positive primary breast cancer.
  • Is current dosing recommendation of voriconazole appropriate for Indian pediatric patients ? - A dose - concentration - efficacy study
  • Morphological and immunohistochemical assessment of ovarian serous carcinomas and its stratification into low grade and high grade serous carcinomas
  • Application of polymerase chain reaction on formalin-fixed and paraffin-embedded tissue for detection of M.tuberculosis.
  • Evaluation of the extent of implementation of evidence based guidelines for the management of esophageal cancers in theTata Memorial Centre
  • Validation of a non-invasive methodology for early diagnosis of oral cancer by assessing skin surface potential and tumor markers in saliva
  • AMC Protocol #S002: A Study of patients in resource-limited areas with cancer who also have HIV
  • A phase III, open label, randomized, multicentre trial of Ofatumumab added to Chlorambucil vs. Chlorambucil Monotherapy in previously untreated patients with Chronic Lymphocytic leukaemia
  • Coping with bereavement- an Indian experience
  • Genomic profiling of oral precancerous lesions and early stages of oral cancer
  • Resilience and Coping Adopted by Families of Children suffering from cancer in Palliative Care
  • Clinopathological Study of Gastrointestinal Stromal Tumors
  • Effect of screening with visual examination and double-contrast barium swallow on oral and upper aerodigestive tract cancer mortality- a cluster -randomized trial
  • Single-arm observational study of etomidate as inducing agent in patients undergoing diagnostic direct laryngoscopy
  • A prospective randomized comparative study between a single dose intravenous paracetamol versus intravenous tramadol for the postoperative analgesia after mild to moderate surgical procedures
  • Pharmacokinetics and pharmacogenetic study of 13-cis-retinoic acid in Indian children with high-risk neuroblastoma
  • A randomized phase III clinical study of bevacizumab plus capecitabine vs. bevacizumab alone as maintenance therapy in patients with HER2-negative metastatic breast cancer that has not progressed during first-line docetaxel plus bevacizumab induction therapy
  • A Phase III, Open Label, Randomized Trial of Ofatumumab Added to Fludarabine-Cyclophosphamide vs. Fludarabine- Cyclophosphamide Combination in Subjects with Relapsed Chronic Lymphocytic Leukemia
  • A retrospective study to evaluate the outcome of ultrasound guided FNAC of neck nodes.
  • A Randomized, Open-Label, Two-Arm Study of Neratinib Plus Paclitaxel Versus Trastuzumab Plus Paclitaxel as First-Line Treatment for ErbB-2-Positive Locally Recurrent or Metastatic Breast Cancer
  • An audit of pain scores during postoperative stay in and at discharge for PACU / Recovery room.
  • Evaluation of marrow involvement by lymphoma by whole body 18F-FDG PET/CT scan.
  • To assess the role of whole body FDG PET/CT in the metastatic staging of Ewings family of tumours
  • Assessment of the reporting quality of non-inferiority and equivalence trials in cancer, pre and post CONSORT, using a modified CONSORT checklist
  • Association of host immunogenetic factors with Human Papillomavirus (HPV) infection in development of cervical cancer in Indian women
  • MRI evaluation of primary bone tumour of long bones
  • Randomized Controlled Trial Evaluating the Role of Exercise in Women Undergoing Treatment for Breast Cancer
  • A pilot project  for evaluation of EGFR mutations in Non-Small cell lung cancer and its role in patients receiving Gefitinib treatment
  • A Phase III Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long-term Safety and Efficacy of Darbepoetin Alfa Administered at 500 ?g Once-Every-3-Weeks in Anemic Subjects With Advanced Stage Non-small Cell Lung Cancer Receiving Multi-cycle Chemotherapy
  • Study of Quality of Life in Patients Undergoing Partial Penectomy for Carcinoma of Penis
  • A randomized trial comparing intensity modulated external beam radiation alone vs intensity modulated radiation and brachytherapy for reduction in xerostomia in patients with early staged orophyarngeal cancers
  • A prospective study of telephonic contact and subsequent physical follow up of radically treated lung cancer patients
  • Study of Quality of life in patients with soft tissue or free fibular graft reconstruction following Mandibulectomy
  • Adaptive Radiotherapy for Childhood Head and Neck Tumours
  • CD200 expression in chronic lymphoproliferative disorders: A prospective study
  • Study of neuroendocrine markers in neuroendocrine tumours of head and neck region as applied on cytology
  • A Double-blind, Randomised, Parallel Group, Phase III Study to Demonstrate,Equivalent Efficacy and Comparable Safety of CT-P6 and Herceptin, Both in Combination with Paclitaxel, in Patients with Metastatic Breast Cancer
  • A Phase I/II multicenter study of IY5511HCl in Philadelphia chromosome positive chronic myeloid leukemia patients without optimal response or tolerance to Bcr-Abl tyrosine kinase inhibitors (Imatinib and/or Dasatinib, Nilotinib).
  • Policy in Practice: Youth Tobacco Use Prevention in Maharashtra, India
  • Evaluation of transthoracic lung FNACs (a five year study)
  • Establishment of registry for Epidemiology and end result - analysis in lymphoma (REEA-L) and Establishment of lymphoma tumor tissue repository at the Tata Memorial Hospital (LTTR)
  • To study the diagnostic usefulness of novel glycan epitope on MUC1, alternatively spliced isoform MUC1/Y, ?, 2-3 Sialyltransferase and ?, 2-6 Sialyltransferase in breast cancer patients.
  • A randomized trial to evaluate the efficacy and safety of Pemetrexed  and Platinum Vs Gefitinib in Non-Small Cell Lung Cancer patients
  • Evaluation of VEGF expression of tumor cells as a potential prognostic marker in Ewing’s sarcoma
  • Androgen receptor expression in breast cancer: Clinical, pathological and prognostic significance
  • Evaluation of stem cells in testicular biopsies of young adult survivors of childhood cancer
  • IAEA CRP on Optimisation of Radiotherapy in Low Resource Settings: Paediatric Cancer Patients (2008-2012)
  • Phase II feasibility study of Oral Metronomic Therapy ME2C in adult patients with relapsed High grade B cell  Non-Hodgkin’s lymphoma not eligible for Stem cell transplantation

Contact Us

Dr. E Borges Road, Parel, Mumbai - 400 012 India
Phone: +91-22- 24177000, 24146750 - 55
Fax: +91-22-24146937
E-mail : msoffice@tmc.gov.in (for patient care and queries) / hrd@tmc.gov.in(for administrative - HRD matters)

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