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Sample Data-Articles

Transperancy Audit

Transperancy Audit

Retention Policy of RTI Files/ Records

Sr. No.

Description of Record

Retention Period

Remarks

1
RTI Application disposed without attracting any first appeal

3 years

-

       
2
RTI Applications with first appeal
5 years from the date of first Appeal

Since they attract second appeal so require a fair retention period

 

 

   

3

RTI Application with second appeal 5 years from the date of appeal or till the compliance of Commission’s order whichever is later

 

 

   
 

Tata Memorial Centre
New Treatment For Cure of Breast Cancer

Press Release

Dr Rajendra Badwe, Director Tata Memorial Centre presented the results of a landmark multicentre Indian breast cancer study at the ongoing European Society of Medical Oncology (ESMO) Congress in Paris on Monday, September 12, 2022. The annual ESMO Congress is one of the most prestigious cancer conferences in the world and is held annually in Europe.

The study, ‘Effect of Peri-tumoral Infiltration of Local Anaesthetic Prior to Surgery on Survival in Early Breast Cancer’ is a randomized controlled trial, conceived and designed by Dr Badwe, who is the principal investigator, and conducted by investigators at 11 cancer centres in India including Tata Memorial Centre in Mumbai over an 11-year period between 2011 and 2022. The study included 1600 women with early breast cancer who were planned to be treated with surgery. Half of these patients constituting the control group, received standard surgery followed by standard post-operative treatment including chemotherapy, hormone therapy and radiotherapy as per guidelines. The other half, constituting the intervention group, received an injection of a commonly used local anaesthesia agent, 0.5% lidocaine, all around the tumor, just prior to surgery. They then underwent standard surgery followed by the same post-operative treatment as was given in the control group. Dr Badwe’s previous research has suggested that there is a window of opportunity just prior to, during, and immediately after surgical removal of the primary cancer when anti-cancer interventions could reduce the risk of development of disseminated stage 4 metastatic cancer later in the lifespan of the patient. Lignocaine, which is a commonly used, inexpensive, local anaesthesia drug, was thought to be one such suitable intervention because of its inhibitory effects on cancer cell division, movement and other anti-cancer properties. Depicted below is the diagrammatic representation of the technique of peri-tumoral injection which is simple and requires no additional expertise.

After completion of treatment patients were followed up regularly for several years to compare the rates of cure and survival between the control group and local anaesthesia group. When enough follow-up had happened in both groups the data was analyzed at a cutoff date of September 2021. As expected, there was no toxicity of lignocaine patients who received it. The 6-year disease-free survival (cure rate) was 81.7% in the control group and 86.1% in the local anaesthesia group for a 26% relative reduction in the risk of cancer relapse or death with the local anaesthesia injection, which was statistically significant. Similarly the 6-year overall survival was 86.2% versus 89.9% in the two groups for a 29% reduction in the risk of death with the local anaesthetic injection, which was also statistically significant. Depicted below are the disease-free survival and overall survival in the two study groups over time.

Disease-free Survival

Overall Survival

These benefits are substantial and were achieved with an intervention the cost of which was less than Rs 100/- per patient. For comparison, benefits of far lesser magnitude have been achieved in early breast cancer patients by much more expensive, targeted drugs which cost more than ten lakhs per patient.

Joining from Paris immediately after his presentation, Dr Badwe commented "This is the first study of its kind globally, that has shown a sizable benefit by single intervention prior to surgery. If implemented across the world, it has the capability to save over 100,000 lives annually. For scientists, it opens the window of peri-operative intervention to modulate the environment of cancer in such a way as to prevent its deleterious reaction to the act of surgery [observation]. Evolving low-cost interventions for cancer has been a mission of Tata Memorial Centre and Department of Atomic Energy for the benefit of Indian and global population and this study, supported by the Department of Atomic Energy, is a major step towards Atma Nirbhar Bharat."

Dr Sudeep Gupta, Professor of Medical Oncology at TMC, Director ACTREC, one of the co-investigators of the study said: “This study provides an inexpensive and immediately implementable treatment in breast cancer which can be practiced by every surgeon who treats this disease. The results from a large randomized trial, which is the gold-standard way of evaluating the worth of new treatments, provides the highest level of evidence to support the use of this technique. This study is proof that Indian centres can design and conduct studies which have a global impact.”

Sr. No.

Institute’s Name

Researcher
1
Tata Memorial Centre, Mumbai,

Dr. Rajendra Badwe
Dr. Sudeep Gupta
Dr. Vani Parmar,
Dr. Nita Nair
Dr. Shalaka Joshi
Ms. Rohini Hawaldar
Ms. Shabina Siddique
Mr. Vaibhav Vanmali
Ms. Ashwini Dewade
Ms. Varsha Gaikawad

2
Kolhapur Cancer Centre, Kolhapur, India Dr. Suraj Pawar
3
Max Superspeciality Hospital, Patparganj, New Delhi, India Dr. Geeta Kadayaprath
4
B. Borooah Cancer Institute, Guwahati, India Dr. Bibhuti Bhusan Borthakur
5
Basavatarakam Indo-American Cancer Hospital and Research Centre, Hyderabad, India Dr. Subramanyeshwar Rao Thammineedi
6
Gujarat Cancer & Research Institute, Ahmadabad, India Dr. Shashank Pandya
7
Malabar Cancer Centre (MCC), Kodiyeri, Thalassery, Kannur, India Dr. Satheesan. B
8
Siddhivinayak Ganapati Cancer Hospital, Miraj, India Dr. P V Chitale
9
Sterling Multi-Speciality Hospital, Pune, India Dr. Rakesh Neve
10
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, India Dr. Caleb Harris
11
All India Institute of Medical Sciences, New Delhi Dr. Anurag Srivastava



       


CONTACT US  

   Ms. Meenakshi Ganeshan/
         Ms. Vaishnavi Darade

Conference Coordinator,

Clinical Research Secretariat (CRS) & DAE-CTC

3rd Floor Main Building Tata Memorial Hospital,

Parel, Mumbai - 400012

 

 Email

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India Tel: +91-22-24177000 Extn: 4254 , 4264 

                    

                Website: https://tmc.gov.in

 

 

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