|
RESEARCH
Several research projects are being carried
out in the department. Majority of these are investigator
initiated and some of them are multicentric.
PROJECTS
| |
Title
of Project
and investigators
|
Date
of Starting
|
Funding
body
|
|
Ongoing
Projects
|
|
1
|
Concomitant chemoradiotherapy
versus accelerated radiotherapy versus conventional
radiotherapy in the management of advanced carcinoma
of the head and neck. S. (Ghosh) Laskar, JP Agarwal,
TK Saikia, KA Dinshaw
|
2000
|
TMH/ CSIR
|
|
2
|
Randomized multicentric study
of 5 v/s 6 weekly fractions of radiotherapy in the treatment
of squamous cell carcinoma of head & neck. JP
Agarwal, SK Shrivastava, S (Ghosh) Laskar, KA Dinshaw
|
2000
|
IAEA/TMH
|
|
3
|
Intraoperative Iridium - 192 tumor
bed implant alone in early breast cancer. Sarin
R, Jalali R, Budrukkar AN, Badwe R, Parmar V, Nadkarni
M, Chinoy R, Shet T, Shrivastava SK, Deshpande DD, Dinshaw
KA
|
2001
|
Nil
|
|
4
|
HDR Brachytherapy Of
Internal Mammary Nodal Chain In Breast Cancer With Intra-Operative
Catheter Placement In The Internal Mammary Vessels.
Sarin R, Badwe R, Jalali R, Mahantshetty U, Budrukkar
A, Parmar V, Nadkarni M, Deshpande DD |
2001
|
Nil
|
|
5
|
Feasibility study to evaluate
and correlate between clinical & sonographic responses
in cervical node metastases in head & neck carcinoma
following radical radiotherapy. S (Ghosh) Laskar,
JP Agarwal, S Arya, T Pandey, P Corea
|
2002
|
TMH
|
|
6
|
Concomitant chemoradiation in
advance stage carcinoma cervix- A phase III Randomised
trial. SK Shrivastava, HB Tongaonkar, S Gupta, R
Kerkar, A Maheshwari, S (Ghosh) Laskar, KA Dinshaw
|
2003
|
TMH/ ICMR
|
|
7
|
Concomitant chemoradiation versus
neo-adjuvant chemotherapy and surgery in the management
stage II carcinoma cervix- A phase III Randomised trial,
S Gupta, HB Tongaonkar,SK Shrivastava, eshwari, S (Ghosh)
Laskar, KA Dinshaw
|
2003
|
TMH/ ICMR
|
|
8
|
Intraluminal HDR brachytherapy
alone versus Intraluminal HDR brachytherapy and External
Beam Radiotherapy in the Palliation of Advanced Oesophageal
Carcinoma. KA Dinshaw, S Ghosh Laskar, SK Shrivastava,
DD Deshpande, RA Kinnhikar
|
2003
|
IAEA/TMH
|
|
9
|
Two vs four cycles of abvd chemotherapy
and low dose radiation therapy in early stage favourable
prognosis hodgkin's disease: a randomised clinical trial.
M.A.Muckaden, .S. Laskar, T.K.Saikia, S.K.Pai, K.Naresh,
S.Gupta
|
2003
|
TMH
|
|
10
|
Hereditary Cancer Consortium.
R Sarin, SS Agarwal, KA Dinshaw K Mohandas, P Kurkure,
R Badwe, H Tangaoankar, A Puri, R Chinoy, R Mulherkar,
P Kadam
|
2002
|
TMH
|
|
11
|
Accelerated Tumor Bed Irradiation
in Early breast cancer with IMRT: A Feasibility and
dosimetric study. R Sarin S Chopra, D Kumar, SS
Narayanan, R Kamble, R Jalali, SK Shrivastava, DD Deshpande,
K A Dinshaw
|
2003
|
TMH
|
|
12
|
Efficacy of stereotactic conformal
radiotherapy (SCRT) compared to conventional radiotherapy
in minimising late sequelae in children and young adults
with brain tumours: a randomised clinical trial (SCRT
trial). R Sarin, R Jalali, N Merchant, S Goswami,
N Shah, KA Dinshaw, et al
|
2001
|
Terry Fox Foundation
|
|
13
|
To prospectively compare tumour
control, late sequalae and quality of life in patients
with non-functioning pituitary adenomas treated with
surgery alone versus surgery followed by radiotherapy:
a randomised trial (pituitary trial). R Jalali,
A Goel, R Sarin, et al
|
2002
|
TMH
|
|
14
|
Radioprotective effect of ocimum
sanctum (Tulsi) in patients undergoing hemibody irradiation:
A double blind randomised trial R Sarin, R Jalali,
SK Shrivastava, MA Muckaden, M Ghatge, AS Raste, KA
Dinshaw
|
2002
|
ICMR grant
|
|
15
|
Prevalence and spectrum of BRCA1
and BRCA2 mutations in familial breast ovarian cancers.
R Sarin, SS Agarwal, R A Badwe, HB Tangaoankar, K.A
Dinshaw
|
2004
|
TMH
|
|
16
|
Prospective neurological function,
quality of life and Barthel's assessment in adult patients
with primary brain tumours. R Jalali, A Bud, R Sar,
R Kamble, S Parab, R Hawaldar
|
2004
|
TMH
|
|
17
|
Feasibility of concomitant electron
boost (on Saturdays) in patients with locally advanced
breast cancer treated with radiotherapy R Jalali,
R Malde, A Budrukkar, R Sarin
|
2004
|
TMH
|
|
18
|
Para-aortic Lymph Node Staging
and Evaluation of Treatment Outcome by 18F-fluorodeoxyglucose
Positron Emission Tomography (FDG-PET) in Advanced Cancer
Cervix. KA Dinshaw, SK Shrivastava, A Samuel, HB
Tongaonkar, R Kerkar, A Maheshwari, S (Ghosh) Laskar.
|
2004
|
TMH
|
|
19
|
Elective versus Therapeutic Neck
Dissection in the Treatment of Early Node Negative Squamous
Cell Carcinoma of the Oral Cavity, AK D'cruz, D
Chaukar, KA Pathak, M Deshpande, P Chaturvedi, P Pai,
RL Bhalawat, S. (Ghosh) Laskar, JP Agarwal, KA Dinshaw
|
2004
|
TMH
|
|
20
|
Randomized Clinical trial to compare
results of Concurrent chemo-radiation with surgery and
post-operative radiotherapy. KA Pathak, M Deshpande,
AK D'cruz, D Chaukar, P Chaturvedi, P Pai, RL Bhalawat,
S. (Ghosh) Laskar, JP Agarwal, PM Parikh, VR Pai, KA
Dinshaw
|
2004
|
TMH
|
|
21
|
A phase II trial of IRESSA in
advanced Head & Neck cancers. D'cruz, D Chaukar,
S. (Ghosh) Laskar, JP Agarwal, KA Dinshaw
|
2004
|
Multicentric: ASTRA-ZENECA
|
|
22
|
Radiotherapy Dose Escalation for
Inoperable Ewing's Sarcoma/ PNET (EFT 2001 RT).
S.Laskar, C.N.Nair, M.A.Muckaden, A.Puri, M.G.Agarwal,
S.Gujral, S.Gupta, S.Banavali,P.Kurkure, S.K.Pai, S.Juvekar,
N.Nair,D.D.Deshpande, S.K.Shrivastava, S.Basu.
|
2004
|
DAE/ CTC
|
|
23
|
Intensified Vincristine, Ifosfamide,
Etoposide with Adriamycin, Cyclophosphamide, and Actinomycin
D in the Treatment of Non-Metastatic Ewing's Family
of Tumors. C.N.Nair, M.A.Muckaden, S.Gupta, S.Banavali,
S.K.Pai, P.A.Kurkure, S.Laskar, A.Puri, M.G.Agarwal,
S.Juvekar, T.Shet, M.Ramadwar, S.Desai, S.Agarwal, N.Nair,
R.Havaldar.
|
2004
|
TMH
|
|
24
|
Intensive versus Routine follow-up
for Soft Tissue Sarcomas. A.Puri, M.G.Agarwal, R.Badwe,
R.Hawaldar, R.Mistry, C.S.Pramesh, S.Laskar, S.Gupta,
N.Jambhekar, M.A.Muckaden, S.Juvekar.
|
2004
|
TMH
|
|
25
|
The Treatment and Characterization
of Acute Lymphoblastic Leukemia in Children, Adolescents
and Young Adults (INCTR 02-04). S.Banavali, P.Kurkure,
C.N.Nair, P.M.Parikh,S.K.Pai, S.Gujral, M.A.Muckaden,
S.Laskar, N.Merchant, S.Goswami, P.Amre, A.Paes, B.Kolhatkar,
R.Hawaldar, N.Thomas.
|
2004
|
TMH/ INCTR
|
|
26
|
Concomitant and adjuvant Temozolomide
with radical radiotherapy in children with brain stem
glioma (brain stem glioma study). R.Jalali, P.Kurkure,
R.Sarin, N.Merchant, T.Gupta
|
2004
|
Hospital Intramural grant
|
|
27
|
IMRT for Craniospinal irradiation
(CSI) - will have preclinical component of dosimetric/modelling
work followed by implementation and feasibility in 5
patients (IMRT-CSI study). R.Jalali, D.Sharma, R.Sarin,
T.Gupta, Reena.P, S.K.Shrivastava, K.A.Dinshaw
|
2004
|
DAE/CTC
|
|
28
|
A phase II randomized trial Comparing
IMRT with conventional radiation therapy in Stage IIB
Carcinoma Cervix.SK Shrivastava, U Mahantshetty,
DD Deshpande, S (Ghosh) Laskar, KA Dinshaw, RA Kinhikar,
Sherly Saju, SV Jemima, HB Tongaonkar, S Gupta.
|
2004
|
Varian Medical Systems LTD.USA
|
|
29
|
Phase II study of 3-Dimentional
Conformal Radiotherapy (3D-CRT) versus Intensity Modulated
Radiotherapy (IMRT) for Squamous Cell Carcinoma of the
Head & Neck (HNSCC).SG Laskar, T Gupta, JP Agarwal,
SK Shrivastava, KA Dinshaw, PM Parikh, VR Pai, Reena
Devi, S Deshpande, DD Deshpande.
|
2005
|
Varian Ltd, USA
|
|
30
|
Phase II study of 3-Dimentional
Conformal Radiotherapy (3D-CRT) versus Intensity Modulated
Radiotherapy (IMRT) for Squamous Cell Carcinoma of the
Head & Neck (HNSCC).Gupta T, Laskar SG, Agarwal
JP, Shrivastava SK, Dinshaw KA, Parikh PM, Pai VR, Reena
Devi, Deshpande S, Deshpande DD.
|
2005
|
Siemens Ltd., USA
|
|
31
|
Para-aortic Lymph Node Staging
and Evaluation of Treatment Outcome by 18F-fluorodeoxyglucose
Positron Emission Tomography (FDG-PET) in Advanced Cancer
Cervix. Dinshaw KA, Shrivastava SK, Samual A, Mahantshetty
U, Laskar SG, Merchant NH, Gupta S, Tongaonkar HB, Rangrajan
V, Purandare N.
|
2005
|
DAE/CTC
|
|
32
|
Comparative evaluation of different
detectors for IMRT dosimetry. Deshpande DD, Kinhikar
RA, Saju Sherley, Narayana SS, Sharma D, Shrivastava
SK, Dinshaw KA.
|
2005
|
Intramural / ACTREC
|
|
33
|
Phase III Trial of Surgery followed
by conventional radiotherapy (5#/Wk) versus concurrent
chemoradiotherapy versus Accelerated radiotherapy (6#/Wk)
in high risk, locally advanced, stage III & IVa,
resectable, squamous cell carcinoma of oral cavity.
Deshpande Mandar, D'Cruz AK, Pathak KA, Chaukar DA,
Chaturvedi P, Pai P, Dinshaw KA, Bhalavat RL, Agarwal
JP, Ghosh S, Pai VR, Mohandas K, Kane SV
|
2005
|
DAE-CTC
|
|
34
|
Temozolomide versus PCV in recurrent
high grade gliomas (BR 12 Trial). A MRC conducted multicenter
randomised trial - R Jalali (Collaborator from TMH).
|
2005
|
MRC/ TMH
|
|
35
|
Timing of systemic chemotherapy
in patients with isolated locoregional recurrence of
breast cancer. Nair R, Gupta S, Badwe R, Parmar
V, Nadkarni M, Sarin R, Jalali R, Budrukkar AN, Hawaldar
R
|
2005
|
|
|
36
|
A phase III trial evaluating the
role of chemotherapy as an adjuvant therapy for premenopausal
women with endocrine responsive breast cancer who receive
endocrine therapy (PERCHE trial). Parmar V, Badwe
R, Nadkarni M, Nair R, Gupta S, Sarin R, Jalali R, Budrukkar
AN, Hawaldar R
|
2005
|
IBCSG
|
|
37
|
A phase III trial evaluating the
role of exemestrane plus GnRH analogue as an adjuvant
therapy for premneopusal women with endocrine responsive
breast cancer (TEXT trial) Parmar V, Badwe R, Nadkarni
M, Nair R, Gupta S, Sarin R, Jalali R, Budrukkar AN,
Hawaldar R
|
2005
|
IBCSG
|
|
Tata Memorial Hospital, Dr.
E Borges Road, Parel, Mumbai - 400 012 India. 